Shen Muhe was originally a medical woman in the Ming Dynasty and a closed door disciple of the Medicine Saint Li Shenyi. Due to dissatisfaction with the oppression and control of women by the feudal dynasty, she chose to die rather than comply after being forced by the powerful and was stabbed in the chest. By a twist of fate, she used the medium of "Compendium of Materia Medica" to exchange her soul with an intern female pharmacist named Cheng Dieyi in modern society. Cheng Die, who has average strength, is taller than the sky and has been immersed in the virtual world of time travel novels, unable to see herself clearly. In this way, two girls from different time and space, by chance, used each other's identities to live lives that were completely different from their past life trajectories. Shen Muhe, who was devoted to advocating freedom and the cause of traditional Chinese medicine, successfully counterattacked and emerged from adversity through his own hard work, promoting the Artemisia argyi industry in his hometown of Qichun County. However, Cheng Dieyi, who was determined to achieve success without hard work, paid a painful price for his greed and ignorance